Human aminopeptidase N is a receptor for human coronavirus 229E.Author RA Williams opens up in an exclusive piece for Female First Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Wisner, A., Dufour, E., Messaoudi, M., Nejdi, A., Marcel, A., Ungeheuer, M.-N., Rougeot, C.

The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis. Impaired angiogenesis in aminopeptidase N-null mice. Rangel, R., Sun, Y., Guzman-Rojas, L., Ozawa, M. H.ĬD13/APN regulates endothelial invasion and filopodia formation. Molecular cloning, expression, and chromosomal localization of the gene encoding a human myeloid membrane antigen (gp150). Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.

H., Olsen, J., Sjostrom, H., Noren, O.Īssignment of the human aminopeptidase N (peptidase E) gene to chromosome 15q13-qter. A., Bolund, L., Grzeschik, K.-H., Ropers, H. K., Sjostrom, H., Noren, O., Laude, H.Īminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV. Sequence comparisons with enzymes of this class showed that CD13 is identical to aminopeptidase N, an enzyme thought to be involved in metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the central nervous system.ĭelmas, B., Gelfi, J., L'Haridon, R., Vogel, L. The remainder of the molecule consists of a large extracellular C-terminal domain that contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily.

Sequence analysis indicated that the hydrophobic segment is not cleaved, but rather serves as both a signal for membrane insertion and as a stable membrane-spanning segment. The predicted 967-amino acid integral membrane protein has a 24-amino acid hydrophobic segment near its N terminus. (1989) determined the complete primary structure of GP150, or CD13. (1986) isolated the complete GP150 gene, or ANPEP, from a human placenta genomic library. A surface antigen glycoprotein of about 150 kD, GP150, is recognized by monoclonal antibodies MY7 and MCS2.

The Class of 86 by R.A. Williams